| Date | Location | Result | |
| 03/03/06 | Dallas, Texas (Moody Coliseum) | Rice 79, Houston 64 | Box score |
| 03/02/06 | Dallas, Texas (Moody Coliseum) | Houston 57, UTEP 40 | Box score |
| 02/26/06 | Birmingham, Ala. (Bartow Arena) | Houston 74, UAB 71 | Box score |
| 02/24/06 | Memphis, Tenn. (Elma Roane Fieldhouse) | Houston 70, Memphis 62 | Box score |
| 02/19/06 | Houston, Texas (Hofheinz Pavilion) | SMU 63, Houston 61 | Box score |
| 02/17/06 | Houston, Texas (Hofheinz Pavilion) | Tulsa 75, Houston 54 | Box score |
| 02/12/06 | El Paso, Texas (Don Haskins Center) | UTEP 77, Houston 67 | Box score |
| 02/10/06 | New Orleans, La. (Fogelman Arena) | Tulane 65, Houston 54 | Box score |
| 02/06/06 | Houston, Texas (Hofheinz Pavilion) | Marshall 57, Houston 50 | Box score |
| 02/03/06 | Houston, Texas (Autry Court) | Houston 75, Rice 62 | Box score |
| 01/29/06 | Houston, Texas (Hofheinz Pavilion) | Houston 64, UTEP 50 | Box score |
| 01/27/06 | Houston, Texas (Hofheinz Pavilion) | Tulane 61, Houston 54 | Box score |
| 01/22/06 | Tulsa, Okla. (Donald W. Reynolds Center) | Tulsa 83, Houston 55 | Box score |
| 01/20/06 | Dallas, Texas (Moody Coliseum) | SMU 66, Houston 53 | Box score |
| 01/15/06 | Houston, Texas (Hofheinz Pavilion) | Houston 79, Rice 72 | Box score |
| 01/13/06 | Greenville, N.C.(Minges Coliseum) | Houston 54, East Carolina 45 | Box score |
| 01/08/06 | Houston, Texas (Hofheinz Pavilion) | Houston 92, Southern Miss 58 | Box score |
| 01/06/06 | Houston, Texas (Hofheinz Pavilion) | Houston 64, UCF 50 | Box score |
| 12/30/05 | Houston, Texas (Hofheinz Pavilion) | Charlotte 80, Houston 71 | Box score |
| 12/20/05 | Houston, Texas (Hofheinz Pavilion) | Houston 78, Prairie View A&M 67 | Box score |
| 12/19/05 | Houston, Texas (Hofheinz Pavilion) | Dartmouth 76, Houston 69 | Box score |
| 12/17/05 | East Lansing, Mich. (Breslin Center) | Michigan State 76, Houston 53 | Box score |
| 12/10/05 | Houston, Texas (Hofheinz Pavilion) | West Virginia 79, Houston 54 | Box score |
| 12/03/05 | Manhattan, Kan. (Bramlage Coliseum) | Houston 63, Texas-Pan American 55 | Box score |
| 12/02/05 | Manhattan, Kan. (Bramlage Coliseum) | Saint Joseph's 69, Houston 45 | Box score |
| 11/30/05 | Omaha, Neb. (Omaha Civic Auditorium) | Creighton 76, Houston 59 | Box score |
| 11/22/05 | Murfreesboro, Tenn. (Murphy Center) | Middle Tennessee 62, Houston 35 | Box score |
| 11/20/05 | Houston, Texas (Hofheinz Pavilion) | Houston 66, Long Beach State 57 | Box score |
| 11/18/05 | Madison, Wis. (Kohl Center) | Wisconsin 77, Houston 54 | Box score |
