| Date | Location | Result | |
| Nov 27, 2010  | Lubbock, Texas   | Texas Tech 35, Houston 20  | Box score |
| Nov 20, 2010  | Hattiesburg, Miss.   | Southern Miss 59, Houston 41  | Box score |
| Nov 13, 2010  | Houston, Texas   | Tulsa 28, Houston 25  | Box score |
| Nov 5, 2010   | Houston, Texas   | UCF 40, Houston 33  | Box score |
| Oct 30, 2010  | Memphis, Tenn.   | Houston 56, Memphis 17  | Box score |
| Oct 23, 2010  | Dallas, Texas   | Houston 45, SMU 20  | Box score |
| Oct 16, 2010  | Houston, Texas   | Rice 34, Houston 31  | Box score |
| Oct 9, 2010   | Houston, Texas   | Mississippi State 47, Houston 24  | Box score |
| Sep 25, 2010  | Houston, Texas   | Houston 42, Tulane 23  | Box score |
| Sep 18, 2010  | Pasadena, CA   | UCLA 31, Houston 13  | Box score |
| Sep 10, 2010  | Houston, Texas   | Houston 54, UTEP 24  | Box score |
| Sep 4, 2010   | Houston, Texas   | Houston 68, Texas State 28  | Box score |
